Specification： 20kg/barrel
chem： 2MgO·3SiO₂·nH₂O
QS： USP46
Usage： This product is insoluble in water and can neutralize excess gastric acid in the stomach and inhibit acid. In terms of drug application dosage form, it is mainly used in tablet, capsule and suspension dosage form.
Character： A white fine powder with no odor or gravel. Insoluble in water.
Chemical formula : 2MgO·3SiO₂·nH₂O
Molecular weight : 260.862
CAS NO. : 14987-04-3
EINECS NO. : 239-076-7
This product is insoluble in water and can neutralize excess stomach acid in the stomach, thereby inhibiting acid. Magnesium trisilicate has a weak neutralizing effect on gastric acid, resulting in a slow and long-lasting effect. Magnesium trisilicate does not produce gas during the process of neutralizing gastric acid. The gel like silica produced after neutralizing gastric acid can cover the surface of ulcers, thereby protecting the gastric mucosa and absorbing toxic and harmful substances and microorganisms in the gastrointestinal tract. Magnesium trisilicate used in large doses has a laxative effect and can be used to alleviate symptoms such as stomach pain, heartburn, and acid reflux caused by excessive stomach acid. Magnesium trisilicate is used as an anti caking agent, filter aid, and coating agent in the food industry.
In terms of drug application dosage forms, magnesium trisilicate are mainly used in tablet, capsule, and suspension forms.
| Inspection Items | Inspection Standards | Internal Standards |
Appearance | No sand feeling white fine powder, no smell,slightly wet | No sand feeling white fine powder, no smell,slightly wet |
Identification | Magnesium salt reaction/silicate reaction | Magnesium salt reaction/silicate reaction |
Acid-neutralizing capacity | NMT140ml&NMT160ml of0.1N HCL | 145-170ml |
Free alkali | Not more than 1.0ml | ≤0.1ml |
Chloride | Not more than 0.055% | ≤0.05% |
Sulfate | Not more than 0.50% | ≤0.45% |
Soluble salt | Not more than 15mg | ≤15ml |
Loss on ignition | Not more than 30.0% | ≤28.5% |
Heavy Metals | Not more than20.0 ppm | ≤20.0ppm |
Arsenic | Not more than 8.0 ppm | ≤8.0ppm |
Plumbum | Not more than 1.3ppm | ≤1ppm |
Magnesium oxide | Not less than20.0% | ≥21.0% |
Silicon dioxide | Not less than45.0% | ≥46.0% |
Ratio of SiO₂ to MgO | 2.10-2.37 | 2.1-2.3 |
Microbiological TEST | ||
Total Viable count | Not more than 10³cfu/g | ≤10²cfu/g |
Yeast & Mold | Not more than 10²cfu/g | ≤10²cfu/g |
E.coli | Negative | Negative |
